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≥ 98.5%
Standard Purity
High-Performance Liquid Chromatography (HPLC) release threshold
< 0.1%
Total Impurities
Strict limitation of structurally related organic impurities
100+ MT
Annual Output
Combined extraction & microbial fermentation capacity
Zero-Stockout
Strategic Buffer
Continuous delivery guarantee for contractual enterprise partners
Technical Whitepaper: Strategic Raw Material
Global Procurement Demand for CAS 138-59-0 (Shikimic Acid)
Shikimic acid (CAS 138-59-0, (3R,4S,5R)-3,4,5-trihydroxycyclohex-1-ene-1-carboxylic acid) represents one of the most critical chiral biochemical scaffolds in industrial chemistry. Serving as the primary upstream starting precursor for the synthesis of Oseltamivir phosphate (Tamiflu) and expanding into advanced cosmetic formulations and fine agrochemicals, maintaining a reliable wholesale pipeline is essential for multinational supply chain resilience.
Antiviral Intermediate Dynamics
CAS 138-59-0 remains irreplaceable in the stereospecific multi-step synthesis of neuraminidase inhibitors. Global pharmaceutical stockpiling strategies against seasonal and pandemic influenza strains (H1N1, H5N1) mandate strict vendor pre-qualification, lot consistency, and high enantiomeric purity to eliminate optical isomers.
- Critical precursor for stereospecific epoxidation pathways
- Eliminates hazardous synthetic steps required by petrochemical starting materials
- Enables high synthetic yields exceeding 35% overall process efficiency
Dermaceutical & Cosmeceutical Growth
The cosmetic industry has experienced an exponential surge in shikimic acid demand. Acting as a non-irritating alternative to glycolic acid and salicylic acid, it exhibits superior tyrosinase inhibition, regulates sebum excretion, and provides powerful anti-microbial action against Cutibacterium acnes.
- Low irritation score compared to traditional α-hydroxy acids (AHAs)
- Dual-action: biological exfoliation plus potent free-radical scavenging
- High water solubility facilitating crystal-clear aqueous formulations
Green Biochemical Synthesis
Beyond pharmaceuticals, CAS 138-59-0 acts as an environmentally benign synthon for bio-based aromatic polymers, functional flavonoids, and crop protection agents. As corporate mandates demand scope-3 decarbonization, replacing petroleum-derived benzene rings with shikimate-pathway intermediates has become an industry priority.
- 100% renewable bio-carbon index verified by C14 isotopic testing
- Zero petroleum-derived halogenated secondary compounds
- Compliant with REACH and global circular economy protocols
Supply Chain Engineering
Macro Industry Landscape & Sourcing Challenges
Historically dependent on the seasonal harvesting of Chinese star anise (Illicium verum), the CAS 138-59-0 ecosystem has undergone a massive industrial transformation. Leading factories have modernized production using hybrid extraction-fermentation models to mitigate volatile market swings and harvest dependencies.
Feedstock Volatility Management
Traditional extraction from Illicium verum typically yields 3% to 7% shikimic acid, exposing international buyers to extreme price fluctuations caused by weather disruptions in southwest China and Southeast Asia. Modern industrial manufacturers prevent price surges by maintaining a strategic geographical reserve network and integrating bio-fermentation backups.
Impurity Profiling & Toxic Quinic Acid Separation
The primary technological challenge in manufacturing CAS 138-59-0 lies in eliminating quinic acid (CAS 77-95-2), an analogue with similar physical characteristics. Inferior manufacturers frequently produce material contaminated with quinic acid that interferes with downstream chiral crystallization. Our state-of-the-art resin column separation processes maintain residual quinic acid at < 0.2%.
Precision Traceability Architecture
Cross-border pharmaceutical and nutritional buyers encounter severe regulatory audits requiring end-to-end provenance. From raw botanical harvest logging to final crystallization solvent residue verification, certified supply chains must provide complete transparency via fully auditable Batch Production Records (BPR).
Analytical Rigor & Pharmacopoeia Verification
Technical Specification Matrix: Pure Shikimic Acid
Every bulk batch of CAS 138-59-0 released from Shaanxi ShineHerb Biotech Co., Ltd. is evaluated under validated HPLC and chiral chromatography protocols. Below are the definitive acceptance criteria mandated for pharmaceutical, cosmetic, and fine chemical applications.
CAS Identifier: 138-59-0 | Empirical Formula: C7H10O5 | Molecular Weight: 174.15 g/mol
Monograph Standard: In-House cGMP & Pharma Intermediate Standard
| Test Parameter | Standard Specification | Typical Factory Result | Analytical Methodology |
|---|---|---|---|
| Appearance | White to off-white crystalline powder | Conforms (Fine crystalline) | Visual / Organoleptic Inspection |
| Assay (Purity via HPLC) | ≥ 98.0% (Standard) / ≥ 99.0% (Pharma Grade) | 99.35% | HPLC-UV (210 nm, C18 Column) |
| Specific Optical Rotation [α]D20 | -175.0° to -185.0° (c=1 in H2O) | -181.2° | Polarimetry (Chiral verification) |
| Melting Point Range | 185.0°C to 189.0°C | 186.4°C – 187.8°C | Capillary Melting Apparatus |
| Loss on Drying | ≤ 1.00% | 0.38% | Thermogravimetric (105°C, 2h) |
| Residue on Ignition (Ash) | ≤ 0.10% | 0.04% | Sulfated Ash (800°C furnace) |
| Heavy Metals (Pb, Cd, As, Hg) | ≤ 10.0 ppm total (As < 1ppm, Pb < 2ppm) | Conforms (< 2.5 ppm total) | ICP-MS (Inductively Coupled Plasma) |
| Residual Solvents | Ethanol ≤ 5000 ppm, Methanol ≤ 3000 ppm | Conforms (Ethanol < 240 ppm) | GC-Headspace (FID Detection) |
| Total Aerobic Microbial Count | ≤ 1,000 CFU/g | < 50 CFU/g | Microbiological Plate Method (EP/USP) |
Next-Gen Metabolic Engineering
To decouple manufacturing from seasonal climatic disruptions, current R&D centers on engineered Escherichia coli and Corynebacterium glutamicum strains. By disrupting the shikimate kinase (aroK/aroL) pathways, microbial fermentation achieves titrations exceeding 60 g/L directly from glucose feedstocks.
Subcritical Continuous Extraction
Our manufacturing facilities implement closed-loop continuous countercurrent extraction using pure water-ethanol systems. By operating under subcritical conditions, extraction cycle times decrease by 70%, while heat-sensitive stereochemical bonds remain protected from thermal degradation.
High-Efficiency Polymorph Crystallization
Using real-time PAT (Process Analytical Technology) driven crystallization, particle size distribution (PSD) is strictly controlled to 80-120 mesh. This uniform particle structure ensures consistent bulk density and rapid dissolution rates for downstream blending.
Global Regulatory Assurance
Audited Compliance & Local Market Support
Procurement security relies on comprehensive documentation and smooth regulatory clearance. ShineHerb Biotech provides complete compliance dossier packs that reduce audit friction for custom clearance and institutional buyer qualification.
Standard Audit Dossier Included
Each production lot is accompanied by a batch-specific COA, fully transparent Manufacturing Process Flowcharts (BPR summaries), SDS conforming to GHS Revision 9, Non-GMO declarations, and TSE/BSE safety statements.
Western Market Regulatory Filings
We provide REACH documentation for European chemical imports, FDA Facility Registrations for U.S. customs entry, and INCI/CosIng dossier filings for cosmetic brands entering the European and East Asian personal care sectors.
DDP Logistics & Temperature Controls
Shikimic acid requires moisture-barrier packaging to prevent agglomeration. All export units feature double-layer polyethylene liners with aluminum foil secondary barriers inside 25 kg fiber drums, supported by optional temperature-controlled DDP shipping services.
✓
ISO 9001:2015
Audited QMS System
Audited QMS System
✓
FDA Registered
U.S. Import Clearance
U.S. Import Clearance
✓
HALAL & KOSHER
Global Dietary Certified
Global Dietary Certified
✓
SGS Third-Party
Assay & Heavy Metal Audited
Assay & Heavy Metal Audited
Enterprise Procurement FAQ
Frequently Asked Technical & Commercial Questions
Key answers regarding analytical assays, packaging protocols, sample testing, and contract manufacturing for CAS 138-59-0 buyers.
What is the standard HPLC assay release specification for CAS 138-59-0?
Our standard commercial batches are released at a minimum assay of 98.0% via HPLC (UV detection at 210 nm using a reverse-phase C18 column). For pharmaceutical clients synthesizing Oseltamivir phosphate intermediates, we produce a dedicated high-purity grade guaranteed at ≥ 99.0% with total individual impurities held strictly below 0.10% and optical rotation monitored via sodium D line polarimetry.
How does your facility isolate Shikimic Acid from Quinic Acid impurities?
Because star anise contains both shikimic and quinic acid, simple solvent crystallization often fails to yield pure product. ShineHerb utilizes a proprietary multi-stage macroporous resin ion-exchange adsorption process followed by secondary fractional recrystallization. This enables complete chemical isolation, yielding a final product with residual quinic acid < 0.20% by chromatographic verification.
Can you provide commercial samples for formulation R&D and analytical qualification?
Yes. We routinely provide 50g to 200g analytical samples accompanied by the real-time lot Certificate of Analysis (COA), HPLC chromatograms, and Material Safety Data Sheet (MSDS). Samples are dispatched via DHL/FedEx courier within 24 to 48 hours for immediate validation in your laboratories.
What export packaging standards are used to ensure shelf stability during marine freight?
Shikimic acid is slightly hygroscopic and prone to caking when exposed to elevated humidity. We package our bulk wholesale powder in 25 kg cardboard fiber drums containing dual food-grade heat-sealed polyethylene inner bags with silica desiccants, shielded by a high-barrier aluminum vacuum pouch. When stored below 25°C in dry conditions away from direct sunlight, the verified shelf life is 24 months.
What commercial terms and certifications are available for international orders?
We support flexible international terms including FOB China main ports (Shanghai, Qingdao, Tianjin), CIF destination airports/seaports, and DDP direct warehouse delivery with customs clearance included. Payments are handled via T/T, L/C at sight, or escrow agreements. Our operations operate under ISO 9001:2015, cGMP protocols, and maintain full compliance with HALAL and KOSHER requirements.
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Request Wholesale Quotation & Audit Dossier
Connect directly with our engineering sales specialists in Xi'an. We offer custom batch sizing, dedicated HPLC batch verification, and commercial FOB/CIF/DDP pricing for high-volume supply contracts.